Coordination microparticle vaccines engineered from tumor cell templates.

A method for encapsulation of individual tumor cells with an epigallocatechin-3-gallate (EGCG)-Al(III) coordination layer, which can be used as potential tumor vaccines, was developed. The interaction between microparticle vaccines and dendritic cells was investigated in vitro. The microparticles (similar to 10 mu m) were efficiently internalized by DCs with enhanced uptake efficiency via actin polymerization and clathrin-mediated endocytosis.