Anti-glioma trichobamide A with an unprecedented tetrahydro-5H-furo[2,3-b]pyrrol-5-one functionality from ascidian-derived fungus Trichobotrys effuse 4729.
CHEMICAL COMMUNICATIONS(2019)
Abstract
Trichobamide A (1), a novel pyrrocidine alkaloid with an unprecedented tetrahydro-5H-furo[2,3-b]pyrrol-5-one moiety, was isolated from the ascidian-derived fungus Trichobotrys effuse 4729. Trichobamide A (1) showed significant inhibition of the proliferation of two glioma cell lines, U251 and SNB19. It induced the up-regulation of P53 expression, which in turn induces the up-regulation of downstream pro-apoptotic gene expression and the down-regulation of anti-apoptotic gene expression.
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Key words
fungus,anti-glioma,ascidian-derived
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