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Monocytes exposed to plasma from patients with Alzheimer's disease undergo metabolic reprogramming.

Hannah Wolfe,Virginia Mela,Aedin M Minogue,Anne-Marie Miller,Chris McGuigan,Laura Williams, Deirdre Lohan,Brian A Lawlor,Marina A Lynch

Neuroscience Research（2019）

Cited 5|Views19
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Abstract
•Plasma from APP/PS1 mice induced an inflammatory phenotype in J774.2 cells.•This was accompanied by increased glycolysis in J774.2 cells.•Plasma from AD, but not MCI patients, increased IL-8 mRNA in THP-1 cells.•This was associated with increased glycolysis.•The data identifies a means of discriminating between MCI and AD.
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Key words
Alzheimer’s disease,MCI,APP/PS1 mice,Plasma,J774.2 cells,THP-1 cells,Inflammatory markers,Glycolysis
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