Retrograde transport of masseter muscle-derived neprilysin to hippocampus.

Takuya Kobayashi,Masazumi Nagai,John D Da Silva,Albert M Galaburda,Sara H Rosenberg,Wataru Hatakeyama,Yukinori Kuwajima,Hisatomo Kondo,Shigemi Ishikawa-Nagai

Neuroscience Letters（2019）

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摘要

•Trigeminal N contained high neprilysin (NEP) protein without the corresponding mRNA.•The discrepancy between mRNA-protein suggested the transport of NEP to trigeminal N.•C2C12 myotube released exosomal NEP (eNEP) in response to cholinergic carbachol.•Masseter exported eNEP to hippocampus via trigeminal N upon muscle contraction.•Masseter derived NEP may contribute to the clearance of amyloid β in hippocampus.

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关键词

AD,NEP,CCh,Aβ,HPC,APP,BBB,TGN,MM,eNEP,MT

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