Unidirectional endobronchial valves for management of persistent air-leaks: results of a multicenter study.
JOURNAL OF THORACIC DISEASE(2018)
Abstract
Background: To evaluate the efficacy of Endo-Bronchial Valves in the management of persistent air-leaks (PALs) and the procedural cost. Methods: It was a retrospective multicenter study including consecutive patients with PALs for alveolar pleural fistula (APF) undergoing valve treatment. We assessed the efficacy and the cost of the procedure. Results: Seventy-four patients with persistent air leaks due to various etiologies were included in the analysis. In all cases the air leaks were severe and refractory to standard treatments. Sixty-seven (91%) patients underwent valve treatment obtaining a complete resolution of air-leaks in 59 (88%) patients; a reduction of air-leaks in 6 (9%); and no benefits in 2 (3%). The comparison of data before and after valve treatment showed a significant reduction of air-leak duration (16.2 +/- 8.8 versus 5.0 +/- 1.7 days; P< 0.0001); chest tube removal (16.2 +/- 8.8 versus 7.3 +/- 2.7 days; P< 0.0001); and length of hospital stay (LOS) (16.2 +/- 8.8 versus 9.7 +/- 2.8 days; P=0.004). Seven patients not undergoing valve treatment underwent pneumo-peritoneum with pleurodesis (n=6) or only pleurodesis (n=1). In only 1 (14%) patient, the chest drainage was removed 23 days later while the remaining 6 (86%) were discharged with a domiciliary chest drainage removed after 157 +/- 41 days. No significant difference was found in health cost before and after endobronchial valve (EBV) implant (P=0.3). Conclusions: Valve treatment for persistent air leaks is an effective procedure. The reduction of hospitalization costs related to early resolution of air-leaks could overcome the procedural cost.
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Key words
Zephyr endobronchial valves (Zephyr EBV),persistent air-leak (PAL),bronchoscopy,alveolar-pleural fistula
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