A phylogenetically conserved hnRNP type A/B protein from squid brain.

•Molecular structure and function of hnRNPA/B class of RNA-binding proteins are phylogenetically conserved.•The propensity of squid hnRNPA/B-like Protein 2 stably dimerize may gives clues about the p65 protein.•The corresponding M9 region of squid hnRNPA/B-like Protein 2 clearly has a role on its subcellular distribution.•Stress induced cytoplasmic granules of squid hnRNPA/B-like Protein 2 may indicate a role of squid protein in stress response.