骨乐冲剂对前体破骨细胞OSCAR、NFATC1表达的影响
Abstract
目的:研究骨乐冲剂对前体破骨细胞OSCAR,NFATC1表达的影响,探讨骨乐冲剂抑制破骨细胞增值和分化作用的机制。方法:采用骨髓细胞培养24 h,取未贴壁细胞进行诱导细胞培养,不同剂量的骨乐冲剂含药血清加入体外培养的前体破骨细胞中,测定前体破骨细胞增值率和骨吸收面积含量及OSCAR,NFATC1的表达。结果:高、中、低浓度骨乐冲剂血清能显著抑制前体破骨细胞OSCAR,NFATC1的表达,并能抑制前体破骨细胞的增殖使骨吸收减少。结论:骨乐冲剂能够抑制前体破骨细胞中OSCAR,NFATC1的表达,减少破骨细胞的增殖与分化。
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Key words
Traditional Chinese medicine,Osteoclasts,Proliferation,Bone resorption
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