Nanoquinacrine sensitizes 5-FU-resistant cervical cancer stem-like cells by down-regulating Nectin-4 via ADAM-17 mediated NOTCH deregulation.

Anmada Nayak,Sarita Das,Deepika Nayak,Chinmayee Sethy,Satya Narayan,Chanakya Nath Kundu

Cellular oncology (Dordrecht)（2019）

引用 33|浏览11

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摘要

Our data indicate that Nectin-4 may play a prominent role in 5-FU resistance of metastatic CC cells and that NQC sensitizes these cells by Nectin-4 deregulation through ADAM-17 inhibition, a major component of the NOTCH signalling pathway.

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关键词

Cervical cancer,Cancer stem cells,5-FU resistance,Nectin-4,Metastasis

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