Effect of CYP3A4, CYP3A5 and ABCB1 Polymorphisms on Intravenous Tacrolimus Exposure and Adverse Events in Adult Allogeneic Stem Cell Transplant Patients.

Issam S Hamadeh,Qing Zhang,Nury Steuerwald,Alicia Hamilton,Lawrence J Druhan, Meredith McSwain,Yordanis Diez,Stephanie Rusin,Yimei Han,James Symanowski,Jonathan Gerber,Michael R Grunwald,Nilanjan Ghosh,Dragos Plesca,Justin Arnall,Jigar Trivedi,Belinda Avalos,Edward Copelan,Jai N Patel

Biology of Blood and Marrow Transplantation（2019）

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摘要

•CYP3A5 polymorphisms did not impact i.v. tacrolimus exposure post-transplant.•CYP3A4 and ABCB1 polymorphisms impacted i.v. tacrolimus exposure post-transplant.•ABCB1 2677TT genotype was associated with increased risk of tacrolimus toxicity.•CYP3A4 and ABCB1 C2677T genotyping may help individualize i.v. tacrolimus dosing.•Pharmacogenomic guidelines should acknowledge differences in i.v. versus oral tacrolimus.

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关键词

CYP3A4,CYP3A5,ABCB1,Polymorphisms,Tacrolimus,Allogeneic stem cell transplant,Toxicity

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