Evaluation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) mutagenicity using in vitro and in vivo Pig-a assays.

Roberta A Mittelstaedt,Vasily N Dobrovolsky,Javier R Revollo,Mason G Pearce,Yiying Wang,Azra Dad,Page B McKinzie,Hans Rosenfeldt,Berran Yucesoy, Raymond Yeager,Shu-Chieh Hu,Yunan Tang,Seonggi Min,Hyun-Ki Kang,Dong-Jin Yang,Mallikarjuna Basavarajappa,Robert H Heflich

Mutation Research/Genetic Toxicology and Environmental Mutagenesis（2019）

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摘要

•NNK was positive in the in vitro Pig-a assay with S9 at ≥100 ug/ml.•NNK was mutagenic in the in vitro Pig-a assay only with S9.•Inhalation exposure to NNK was negative in the rat Pig-a assay.•The negative in vivo result is due to insufficient bone marrow exposure.

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关键词

Tobacco constituent,In vitro to in vivo extrapolation,Sprague-Dawley rat,Inhalation,Mutation spectra

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