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Application of Deep Mutational Scanning in Hepatitis C Virus.

Nicholas C Wu,Hangfei Qi

Methods in molecular biology (Clifton, N.J.)（2019）

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Abstract
Mutagenesis is one of the key techniques in virus research. The recent development of deep mutational scanning allows the assessment of replication fitness effects of a large number of viral mutants in a high-throughput manner. Here, we describe a protocol for studying hepatitis C virus (HCV) using deep mutational scanning, which includes the methodologies for mutant library construction, passaging, sequencing, and data analysis.
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Key words
Deep mutational scanning,HCV,Mutagenesis,Next-generation sequencing,Viral fitness
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