Novel, potent, selective, and brain penetrant phosphodiesterase 10A inhibitors.
Bioorganic & Medicinal Chemistry Letters（2019）
Abstract
•Novel PDE10 inhibitors.•Optimization supported by X-ray crystal structure analysis and molecular modeling.•Potent, selective, and brain penetrant.•Improved PK profile (rat): lower clearance in vivo and decreased volume of distribution (compared to WEB-3).
MoreTranslated text
Key words
Phosphodiesterase,PDE10A,WEB-3
AI Read Science
Must-Reading Tree
Example
Generate MRT to find the research sequence of this paper
Chat Paper
Summary is being generated by the instructions you defined