Vasorelaxant and antihypertensive effects of Tianshu Capsule on rats: An in vitro and in vivo approach.

Chang Chen,Cong Guo,Jian Gao,Kaifeng Shi,Jingtang Cheng,Jun Zhang,Sha Chen,Yan Liu,An Liu

Biomedicine & Pharmacotherapy（2019）

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摘要

•Antihypertensive effect of Tianshu Capsule (TSC) is associated with vasorelaxation.•TSC-induced vasorelaxation via both endothelium-dependent and -independent pathway.•The NO/sGC/cGMP pathway, K+ and Ca2+ channels were involved in this vasorelaxation.

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关键词

AC,Ach,BaCl2,EDHF,eNOS,HR,IDO,KCL,KH,L-NAME,NO,ODQ,PGI2,Phe,SBP,SD,sGC,SHRs,SQ22536,TCM,TSC,WKYs,4-AP

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