Synthetic lethality between DNA repair factors Xlf and Paxx is rescued by inactivation of Trp53.

Sergio Castañeda-Zegarra,Mengtan Xing,Raquel Gago-Fuentes,Siri Sæterstad,Valentyn Oksenych

DNA Repair（2019）

引用 17|浏览6

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摘要

•Inactivation of Trp53 gene rescues synthetic lethality between Xlf and Paxx in mice.•Combined inactivation of Xlf and Paxx leads to severe B and T lymphocytopenia in adult mice.•Inactivation of one allele of Trp53 rescues synthetic lethality between Xlf and Dna-pkcs genes in mice.•Combined inactivation of Paxx and Dna-pkcs results in live-born fertile Paxx-/-Dna-pkcs-/- mice.

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关键词

Synthetic lethality,Genetic interaction,SCID,B lymphocyte,Cernunnos

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