USP25 promotes endotoxin tolerance via suppressing K48-linked ubiquitination and degradation of TRAF3 in Kupffer cells.

Jian Wen,He Bai,Nan Chen,Wenfeng Zhang,Xiwen Zhu,Peizhi Li,Jianping Gong

Molecular Immunology（2019）

引用 12|浏览5

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摘要

•USP25 has physical interactions with TRAF3.•USP25 prevents ubiquitination and degradation of TRAF3 in Kuppfer cells.•Stable expression of TRAF3 blunts inflammatory response.•The USP25-TRAF3 pathway is critical for endotoxin tolerance.

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关键词

USP25,TRAF3,Endotoxin tolerance,Kupffer cells

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