Cancer cell membrane-cloaked mesoporous silica nanoparticles with a pH-sensitive gatekeeper for cancer treatment.

•CaCO3 capped mesoporous silica nanoparticles with surface camouflaged with cancer cell membrane.•The nanoparticles is constructed only by naturally biomaterials.•The nanoparticles combine biocompatibility, pH-sensitive drug release and homotypic targeting.•The nanoparticles efficiently inhibited prostate tumor growth.