Imaging Glial Activation In Patients With Post-Treatment Lyme Disease Symptoms: A Pilot Study Using [C-11]Dpa-713 Pet
JOURNAL OF NEUROINFLAMMATION(2018)
Abstract
The pathophysiology of post-treatment Lyme disease syndrome (PTLDS) may be linked to overactive immunity including aberrant activity of the brain's resident immune cells, microglia. Here we used [C-11]DPA-713 and positron emission tomography to quantify the 18kDa translocator protein, a marker of activated microglia or reactive astrocytes, in the brains of patients with post-treatment Lyme disease symptoms of any duration compared to healthy controls. Genotyping for the TSPO rs6971 polymorphism was completed, and individuals with the rare, low affinity binding genotype were excluded. Data from eight brain regions demonstrated higher [C-11]DPA-713 binding in 12 patients relative to 19 controls. [C-11]DPA-713 PET is a promising tool to study cerebral glial activation in PTLDS and its link to cognitive symptoms.
MoreTranslated text
Key words
[C-11]DPA-713, Microglia, Post-treatment Lyme disease syndrome, Neuroimaging
AI Read Science
Must-Reading Tree
Example
![](https://originalfileserver.aminer.cn/sys/aminer/pubs/mrt_preview.jpeg)
Generate MRT to find the research sequence of this paper
Chat Paper
Summary is being generated by the instructions you defined