Withdrawal symptoms predict prescription opioid dependence in chronic pain patients.

Ainhoa Coloma-Carmona,José L Carballo,Jesús Rodríguez-Marín,Ana Pérez-Carbonell

Drug and Alcohol Dependence（2019）

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摘要

•Opioid analgesics withdrawal is strongly associated with DSM-5 opioid-use disorder.•Withdrawal intensity increases with the severity of opioid-use disorder and pain.•Withdrawal intensity increases with smoking and young age.•Prescription of anxiolytics and antidepressants with opioids increases withdrawal.•Escalation of withdrawal symptoms could predict POUD in chronic pain patients.

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关键词

Chronic pain,Prescription opioids,Opioid withdrawal,DSM-5

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