Local mutational diversity drives intratumoral immune heterogeneity in non-small cell lung cancer.
Nature communications(2018)
摘要
Combining whole exome sequencing, transcriptome profiling, and T cell repertoire analysis, we investigate the spatial features of surgically-removed biopsies from multiple loci in tumor masses of 15 patients with non-small cell lung cancer (NSCLC). This revealed that the immune microenvironment has high spatial heterogeneity such that intratumoral regional variation is as large as inter-personal variation. While the local total mutational burden (TMB) is associated with local T-cell clonal expansion, local anti-tumor cytotoxicity does not directly correlate with neoantigen abundance. Together, these findings caution against that immunological signatures can be predicted solely from TMB or microenvironmental analysis from a single locus biopsy.
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关键词
Tumour biomarkers,Tumour heterogeneity,Tumour immunology,Science,Humanities and Social Sciences,multidisciplinary
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