Regulation of inositol 1,4,5-trisphosphate-induced Ca 2+ release from the endoplasmic reticulum by AMP-activated kinase modulators.

Jessica Arias-Del-Val,Jaime Santo-Domingo,Paloma García-Casas,Pilar Alvarez-Illera,Antonio Núñez Galindo,Andreas Wiederkehr,Rosalba I Fonteriz,Mayte Montero,Javier Alvarez

Cell Calcium（2019）

引用 9|浏览12

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摘要

•The AMPK activator A769662 inhibited ER-Ca2+-release mediated by the IP3R.•The AMPK inhibitor dorsomorphin activated ER-Ca2+-release mediated by the IP3R.•Our data suggest that AMPK negatively regulates IP3R.•Phosphoproteomic data suggests some candidates to mediate IP3R modulation.

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关键词

AMPK,ER,MAMs,IP3,IP3R,MCU,BMPR

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