Non-steroidal anti-inflammatory drugs increase MRP4 expression in an endometriotic epithelial cell line in a PPARa dependent manner.

I Massimi,F M Pulcinelli, V P Piscitelli, L Alemanno, T Maltese,M L Guarino,R Marci,G O Canny, L Frati,M Mallozzi,A Frega,D Caserta

European review for medical and pharmacological sciences（2018）

Cited 4|Views67

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Abstract

MRP4 expression was increased in cells treated with NSAIDs and the nuclear receptor PPARa is involved. Elevated PGE2 levels in cell supernatants correlate with its increased transport by MRP4 after NSAID treatment. More importantly, we provide evidence that in endometriotic epithelial cells aspirin and non-aspirin NSAIDs treatments alter gene expression.

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Key words

Endometriosis,MRP4/ABCC4,Pain,Aspirin,NSAID

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