Evodiamine prevents dextran sulfate sodium-induced murine experimental colitis via the regulation of NF-κB and NLRP3 inflammasome.

Peng Shen,Zecai Zhang,Kunpeng Zhu,Hongyang Cao,Jiuxi Liu,Xiaojie Lu,Yanxin Li,Yue Jing,Xin Yuan,Yunhe Fu,Yongguo Cao,Naisheng Zhang

Biomedicine & Pharmacotherapy（2019）

引用 66|浏览3

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摘要

•Evodiamine alleviated dextran sulfate sodium (DSS)-induced mice experimental colitis.•Evodiamine suppressed pro-inflammatory cytokines through regulating NF-κB signal and NLRP3 inflammasome activation.•Evodiamine modulated DSS-induced decrease in the expression of ZO-1 and occludin.•Evodiamine re-balanced Escherichia coli and Lactobacillus levels.•Evodiamine reduced the plasmatic lipopolysaccharide concentration.

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关键词

Evodiamine,Colitis,Inflammation,Intestinal microbiota,Intestinal barrier

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