Astaxanthin ameliorates scopolamine-induced spatial memory via reduced cortical-striato-hippocampal oxidative stress.

•Scopolamine impaired spatial learning in Swiss albino mice.•Scopolamine altered region specific oxidative stress.•Cortical-striato-hippocampal neuronal oxidative stress might be associated with the behavioral deficits.•Behavioral deficits and oxidative stress can be attenuated via astaxanthin.