Lysophosphatidic acid receptor type 2 activation contributes to secondary damage after spinal cord injury in mice.

Clara López-Serrano,Eva Santos-Nogueira,Isaac Francos-Quijorna, Marina Coll-Miró,Jerold Chun,Rubèn López-Vales

Brain, Behavior, and Immunity（2019）

引用 25|浏览3

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摘要

•LPA2 is upregulated in the spinal cord parenchyma after traumatic injury.•LPA2 signaling leads to demyelination.•Microglia express LPA2 in the adult CNS, but also in cell culture conditions.•LPA2 signaling in microglia triggers oligodendrocyte cell death.•Microglia LPA2 cytotoxicity is mediated by activation of P2X7 on oligodendrocytes.

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关键词

Demyelination,Lysophosphatidic acid,Inflammation,Neurodegeneration,Microglia,Spinal cord injury

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