Annexin A2 associates to feline calicivirus RNA in the replication complexes from infected cells and participates in an efficient viral replication.

Juan Carlos Santos-Valencia,Clotilde Cancio-Lonches,Adrian Trujillo-Uscanga, Beatriz Alvarado-Hernández,Anel Lagunes-Guillén,Ana Lorena Gutiérrez-Escolano

Virus Research（2019）

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摘要

•AnexA2 is in vitro associated with the 3′UTR from the FCV RNA.•AnxA2 is associated with the viral RNA in the replication complexes from FCV.•AnxA2-knockdown causes a reduction in FCV protein and dsRNA production.•AnxA2-knockdown causes a decrease of FCV production.•AnxA2 is required for an efficient FCV production.

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关键词

Feline calicivirus,Annexin A2,RNA-protein interaction,Viral replication,Replication complexes

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