Neonatal lipopolysaccharide challenge induces long-lasting spatial cognitive impairment and dysregulation of hippocampal histone acetylation in mice.

•Neonatal LPS-challenge triggers long-lasting spatial cognitive impairment.•Neonatal LPS-challenge induces dysregulation of hippocampal histone acetylation in adult mice.•Neonatal LPS-challenge impairs hippocampal c-Fos expression in response to spatial learning.•TSA rescues LPS challenge-induced spatial cognitive impairment and c-Fos gene expression deficit.