Synthesis, bioactivity and molecular modeling studies on potential anti-Alzheimer piperidinehydrazide-hydrazones.

Sulunay Parlar,Gozde Sayar,Ayse Hande Tarikogullari,Sumru Sozer Karadagli,Vildan Alptuzun,Ercin Erciyas,Ulrike Holzgrabe

Bioorganic Chemistry（2019）

引用 16|浏览10

暂无评分

摘要

•N-benzylpiperidine-3/4-carbohydrazide-hydrazones were designed and synthesized.•They were evaluated for AChE/BuChE/Aβ42 inhibitory and antioxidant activities.•The final compounds exhibited AChE and BuChE inhibitory activity.•The nitro derivative (1g) showed good Aβ anti-aggregation properties.•1g and 1j exhibited the best profile as multi-target lead compounds for AD treatment.

查看译文

关键词

Hydrazone,Acetylcholinesterase/Butyrylcholinesterase inhibitory,Ellman method,Thioflavin T test,Antioxidant activity,Molecular modeling,Synthesis

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要