Specific Bacteria and Metabolites Associated with Response to Fecal Microbiota Transplantation in Patients with Ulcerative Colitis.

Sudarshan Paramsothy,Shaun Nielsen,Michael A Kamm,Nandan P Deshpande,Jeremiah J Faith,Jose C Clemente,Ramesh Paramsothy,Alissa J Walsh, Johan van den Bogaerde,Douglas Samuel,Rupert W L Leong,Susan Connor,Watson Ng,Enmoore Lin,Thomas J Borody,Marc R Wilkins,Jean-Frederic Colombel,Hazel M Mitchell,Nadeem O Kaakoush

Gastroenterology（2019）

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摘要

In an analysis of fecal and colonic mucosa samples from patients receiving FMT for active UC and stool samples from donors, we associated specific bacteria and metabolic pathways with induction of remission. These findings may be of value in the design of microbe-based therapies for UC. ClinicalTrials.gov no: NCT01896635.

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FOCUS Trial,Inflammatory Bowel Diseases,Microbiome,Metabolism

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