Autophosphorylation of F-actin binding domain of CaMKIIβ is required for fear learning.

Karam Kim,Akio Suzuki,Hiroto Kojima,Meiko Kawamura,Ken Miya,Manabu Abe,Ikuko Yamada,Tamio Furuse,Shigenaru Wakana,Kenji Sakimura,Yasunori Hayashi

Neurobiology of Learning and Memory（2019）

引用 6|浏览28

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摘要

•Knock-in mouse carrying lasting CaMKII-actin binding shows normal brain morphology.•KI mouse is more active in open field test.•KI mouse shows an impairment in contextual and cued fear conditioning tests.

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关键词

Ca2+/calmodulin-dependent protein kinase II,Actin cytoskeleton,Synaptic plasticity,Mouse behavior battery,Learning and memory,Fear conditioning test,Phosphorylation,Knock-in mouse

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