Developing a Novel Ambulatory Total Parenteral Nutrition-Dependent Short Bowel Syndrome Animal Model.

Amber Price,Keith Blomenkamp,Chandrashekhara Manithody,Saurabh Saxena,Salim Munoz Abraham,Jose Greenspon,Gustavo A Villalona,Ajay Kumar Jain

Journal of Surgical Research（2019）

引用 5|浏览23

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摘要

We created a novel, ambulatory TPN-SBS model using piglets, mimicking long-term TPN delivery in human SBS patients. Our model demonstrated TPN-related conjugated hyperbilirubinemia and compensatory gut hypertrophy, as noted in humans with SBS. This model holds great potential for future research.

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关键词

Model,Animal,TPN,Short bowel syndrome,Ambulatory,Cholestasis,Gut atrophy

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