Overexpression of apelin in Wharton' jelly mesenchymal stem cell reverses insulin resistance and promotes pancreatic β cell proliferation in type 2 diabetic rats.
Stem cell research & therapy（2018）
摘要
In this study, we report a novel approach to treat type 2 diabetic rats that combines apelin gene therapy with WJ-MSC cell therapy, which could provide a promising therapeutic option for management of type 2 diabetes clinically.
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关键词
Apelin,Lentiviral transduction,Mesenchymal stem cells,Type 2 diabetes,Wharton’s jelly,ß cell proliferation
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