Glucocorticoid insensitivity by staphylococcal enterotoxin B in keratinocytes of allergic dermatitis is associated with impaired nuclear translocation of the Glucocorticoid Receptor α.

Ke Huang,Lei Ran,Wei Wang,Rong Zhou,Xiaowei Cai,Ran Li,Yuanchao Li,Chunli Zhou,Wei He,Rupeng Wang

Journal of Dermatological Science（2018）

引用 4|浏览9

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摘要

•SEB induces insensitivity to glucocorticoids in atopic dermatitis.•SEB inhibits dexamethasone-induced GRα nuclear translocation in keratinocytes.•Accumulation of cytoplasmic GRα is related to elevation of FKBP51 in HaCaT cells.

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关键词

Staphylococcal superantigens,Keratinocytes,Glucocorticoid insensitivity,Nuclear translocation,FKBP51

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