Wuzhi capsule (Schisandra Sphenanthera extract) attenuates liver steatosis and inflammation during non-alcoholic fatty liver disease development.

•Wuzhi capsule was used to protect liver but there was no study explored the mechanism of how Wuzhi capsule inhibit liver steatosis induced by MCD diet.•This study confirmed for the first time that Wuzhi capsule could regulate β-oxidation in livers of mice feed with MCD diet.•We found that WZ capsule could inhibit inflammation via NF-kB signalling pathway in mice feed with MCD diet.•We proved that Wuzhi capsule could regulate NF-kB and PPAR at the same time in mice with fat liver induced by MCD diet.•We found that PPAR benefits mice with fat liver through regulating metabolism of fat but not relieving inflammation in liver under the effects of WZ.