Human B cells fail to secrete type I interferons upon cytoplasmic DNA exposure.

Anna M Gram,Chenglong Sun,Sanne L Landman,Timo Oosenbrug,Hester J Koppejan,Mark J Kwakkenbos,Rob C Hoeben,Søren R Paludan,Maaike E Ressing

Molecular Immunology（2017）

引用 28|浏览11

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摘要

•Human B cells fail to secrete IFN I upon cytoplasmic DNA exposure.•Uninfected human B cells lack detectable levels of STING protein.•EBV+ B cells express STING, yet their cGAS-STING pathway remains dysfunctional.

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关键词

IFN I,IFI16,cGAMP,cGAS,STING,TBK1,IRF3,ISG,PRR,TLR,RIG-I,MDA5,HSV-1,HCMV,KSHV,EBV,PBMC,B-LCL,FAM,poly(I:C)

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