A biofunctionalizable ink platform composed of catechol-modified chitosan and reduced graphene oxide/platinum nanocomposite.
BEILSTEIN JOURNAL OF NANOTECHNOLOGY(2017)
Abstract
We present an ink platform for a printable polymer-graphene nanocomposite that is intended for the development of modular biosensors. The ink consists of catechol-modified chitosan and reduced graphene oxide decorated with platinum nanoparticles (rGO-Pt). We modified the chitosan with catechol groups, in order to obtain adhesive properties and improve solubility. Dispersions of rGO-Pt in ethylene glycol were admixed with an aqueous solution of modified chitosan to yield an ink that is suitable for non-contact piezoelectric printing using a commercial microplotter (Sonoplot GIX Microplotter Desktop). As a proof of concept, printed patterns were biofunctionalized with DNA oligonucleotide probes for Streptococcus agalactiae (Group B streptococcus) using glutaraldehyde as a linker. Confocal microscopy revealed the successful hybridization of complementary polymerase chain reaction (PCR) products and low non-specific binding. Our results demonstrate that catechol-modified chitosan/rGO-Pt nanocomposites can be used as inks for piezoelectric printing and facilitate the attachment of biorecognition elements for biosensor applications.
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Key words
biosensing,catechol,chitosan,graphene,piezoelectric printing
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