T-cell Responses in Individuals Infected with Zika Virus and in Those Vaccinated Against Dengue Virus.

Dominic Paquin-Proulx,Fabio E Leal,Cassia G Terrassani Silveira,Alvino Maestri,Claudia Brockmeyer,Shannon M Kitchen, Vinicius D Cabido,Esper G Kallas,Douglas F Nixon

Pathogens & immunity（2017）

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摘要

We demonstrated that vaccination against DENV induced a T-cell response against ZIKV and identified one such CD4+ T-cell epitope. The ZIKV-reactive CD4+ T cells induced by DENV vaccination and identified in this study could contribute to the appearance of cross-reactive antibodies mediating ADE.

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关键词

CD4,ELISPOT,IFNγ,T cell,antibody dependent enhancement,dengue virus,zika virus

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