The relationship between tumor necrosis factor-α polymorphisms and gastric cancer risk: An updated meta-analysis.

The aim of the present study was to evaluate the relationship between tumor necrosis factor-alpha (TNF-alpha) and the development of gastric cancer, and to investigate whether it can be used as a biological marker for gastric cancer. In the current study, a new meta-analysis was performed to assess the association between TNF-alpha gene polymorphisms and gastric cancer susceptibility. Subgroup analyses based on ethnicity, control population source and non-cardia cancers were also conducted. Summary odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using a random-effects model. TNF-alpha 308 polymorphisms indicated a significant relationship with gastric cancer risk among a normal population [GA/AA vs. GG; 1.17 (1.10-1.23)]. In analysis stratified by ethnicity, TNF-alpha 238 displayed an association with gastric cancer risk in eastern populations [GA/AA vs. GG: 1.24 (1.02-1.50)], but not in western populations [GA/AA vs. GG: 0.96 (0.79-1.18)]. The overall ORs (95% CIs) for TNF-alpha 857, TNF-alpha 1031 and TNF-alpha 863 were 1.13 (1.04-1.24), 0.94 (0.85-1.05) and 0.89 (0.78-1.02), respectively, under dominant genetic model comparison. Among the above three SNPs, only TNF-alpha 857 was robustly associated with gastric cancer inclination, and this association remained consistently robust when limited to non-cardia gastric cancers [GA/AA vs. GG: 1.16 (1.03-1.31)]. TNF-alpha 308 and TNF-alpha 857 genotypes were potential risk factors of statistical significance in gastric cancer, and TNF-alpha 238 indicated to be significantly associated with gastric cancer risk only in eastern populations. TNF-alpha 1031 and TNF-alpha 863 were not significantly associated with gastric cancer risk.