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Nicotinamide induces mitochondrial-mediated apoptosis through oxidative stress in human cervical cancer HeLa cells.

Yi Feng,Yonghua Wang,Chengrui Jiang,Zishui Fang, Zhiqiang Zhang,Xiaoying Lin,Liwei Sun,Weiying Jiang

Life Sciences（2017）

Cited 20|Views6
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Abstract
Our study revealed that nicotinamide induced the apoptosis through oxidative stress and intrinsic mitochondrial apoptotic pathways in HeLa cell. The results emerge that nicotinamide may be an inexpensive, safe and promising therapeutic agent or a neoadjuvant chemotherapy for cervical cancer patients, as well useful to find new drugs for cervical cancer therapy.
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Key words
Nicotinamide,Oxidative stress,Mitochondrial apoptotic pathway,Cervical cancer
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