Structural interplay of K V 7.1 and KCNE1 is essential for normal repolarization and is compromised in short QT syndrome 2 (K V 7.1-A287T).

normal repolarization and is compromised in short QT syndrome 2 (KV7.1-A287T) Ina Rothenberg, PhD, Ilaria Piccini, PhD, Eva Wrobel, PhD, Birgit Stallmeyer, PhD, Jovanca Müller, MD, Boris Greber, PhD, Nathalie Strutz-Seebohm, PhD, Eric Schulze-Bahr, MD, Nicole Schmitt, PhD, Guiscard Seebohm, PhD From the Institute for Genetics of Heart Diseases (IfGH), Department of Cardiovascular Medicine, University Hospital Münster, Münster, Germany, Human Stem Cell Pluripotency Laboratory, Max Planck Institute for Molecular Biomedicine, Münster, Germany, Chemical Genomics Centre of the Max Planck Society, Dortmund, Germany, Interdisziplinäres Zentrum für Klinische Forschung Münster (IZKF Münster) and Innovative Medizinische Forschung (IMF Münster), Faculty of Medicine, University of Münster, Münster, Germany, and Danish National Research Foundation Centre for Cardiac Arrhythmia, Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.