Human CTP synthase filament structure reveals the active enzyme conformation

Eric M Lynch,Derrick R Hicks,Matthew Shepherd,James A Endrizzi,Allison Maker,Jesse M Hansen,Rachael M Barry,Zemer Gitai,Enoch P Baldwin,Justin M Kollman

NATURE STRUCTURAL & MOLECULAR BIOLOGY（2017）

引用 133|浏览25

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摘要

The human enzyme CTP synthase forms polymeric filaments with increased catalytic activity, in contrast to the inactive filaments formed by bacterial CTP synthase. Cryo-EM and crystallographic analyses explain the structural bases for those different behaviors.

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关键词

Cryoelectron microscopy,Enzyme mechanisms,Transferases,X-ray crystallography,Life Sciences,general,Biochemistry,Protein Structure,Membrane Biology,Biological Microscopy

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