Structural insight into allosteric modulation of protease-activated receptor 2

NATURE（2017）

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摘要

Crystal structures of protease-activated receptor 2 (PAR2) in complex with two different antagonist ligands and with a blocking antibody reveal binding sites that are distinct from those found on PAR1, offering new leads for structure-based drug design.

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关键词

Pharmacology,Receptor pharmacology,X-ray crystallography,Science,Humanities and Social Sciences,multidisciplinary

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