Strain Improvement Of Lentzea Sp 7887 For Higher Yield Per Unit Volume On Hydroxylation Of Cyclosporine Derivative Fr901459
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY(2017)
Abstract
A Gram-positive bacterium Lentzea sp. 7887 hydroxylates a cyclosporine derivative FR901459 into AS1837812 (9-hydroxide), which is an important intermediate of candidate drugs that target the hepatitis C virus. We screened a UV-induced mutant, named M-1, which showed about 1.2-fold higher conversion yields, 2-fold higher substrate concentrations (3.69 mM), and 2.5-fold higher yield per unit volume than the wild-type strain.
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Key words
mutation, bioconversion, Lentzea, pilot scale, cyclosporine derivative
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