DNA methylated alleles of the phenylalanine hydroxylase promoter remodeled at elevated phenylalanine levels in newborns with hyperphenylalaninemia.

Chike Bellarmine Item,Somayeh Farhadi,Andrea Schanzer,Susanne Greber-Platzer

Clinical Biochemistry（2017）

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摘要

•Remodeling of methylated alleles at elevated phenylalanine levels•Remodeled methylated alleles as early biomarker for elevated phenylalanine exposure

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关键词

Hyperphenylalaninemia,Phenylalanine hydroxylase,Epigenetics,DNA methylation,Newborn

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