PM 2.5 -induced alterations of cell cycle associated gene expression in lung cancer cells and rat lung tissues.
Environmental Toxicology and Pharmacology(2017)
Abstract
•Our study explored and characterized the expressions of cell cycle-associated genes induced by urban PM2.5 in H292 and rat lung tissues.•The expressions of p53 and CDK2 play a crucial role in the early phase of exposure.•Cdc2 and cyclin B expressions are important in mid-term, while the expression of p21 was predominant in long-term exposure.•The degree of PM2.5-induced damage to trachea and lung tissue was time-dependent.
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Key words
PM2.5,p53,p21,Cell division cycle 2,Cyclin-dependent kinase 2,Cyclin B
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