Protective effects of angiopoietin-like 4 on the blood-brain barrier in acute ischemic stroke treated with thrombolysis in mice.

Bin Zhang,Xiaofeng Xu,Xiuli Chu, Xiaoyang Yu,Yuwu Zhao

Neuroscience Letters（2017）

引用 14|浏览9

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摘要

•ANGPTL4 combined tPA thrombolysis could reduce the ischemic area and improve neurological deficit better.•ANGPTL4 inhibited tPA-mediated side effect of blood brain barrier permeability after thrombolysis.•ANGPTL4 may be a viable therapeutic target for ischemic stroke thrombolysis treatment.

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关键词

BBB,tPA,ANGPTL4,VEGF,MCAO,TTC,MMP-2,MMP-9,ECL,RT

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