Safety and immunogenicity of mammalian cell derived and Modified Vaccinia Ankara vectored African swine fever subunit antigens in swine.

Jaime Lopera-Madrid,Jorge E Osorio,Yongqun He,Zuoshuang Xiang,L Garry Adams,Richard C Laughlin,Waithaka Mwangi, Sandesh Subramanya,John Neilan,David Brake,Thomas G Burrage,William Clay Brown,Alfonso Clavijo,Mangkey A Bounpheng

Veterinary Immunology and Immunopathology（2017）

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摘要

•Reverse vaccinology was applied to identify and rank ASFV immunogenic candidates .•Selected ASFV immunogenic candidate proteins were expressed in HEK-293 mammalian cells and MVA constructs .•Immunizations with antigens purified from HEK-293 cells and MVA constructs in swine were safe .•Immunizations with selected antigens induced ASFV-specific antibodies and T-cell responses in swine.

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关键词

African swine fever virus,Vaccine development,Reverse vaccinology,Recombinant protein expression,MVA,HEK-293

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