Multifunctional silver nanocluster-hybrid oligonucleotide vehicle for cell imaging and microRNA-targeted gene silencing

Hau-Yun Chen,Karunya Albert, Cheng-Che Wen,Pei-Ying Hsieh,Sih-Yu Chen, Nei-Chung Huang,Shen-Chuan Lo,Jen-Kun Chen,Hsin-Yun Hsu

Colloids and Surfaces B: Biointerfaces（2017）

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摘要

An “all-in-one” silver nanocluster (MUC1-AgNCm)-based microRNA(miR-34a) nanocarrier to enable downstream oncogenic gene siliencing (BCL2, CCND1 and CDK6 are genes targeted by miR-34a; ORF: open reading frame; MCF-7: human breast adenocarcinoma cell).

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关键词

Silver nanocluster,microRNA,Human breast adenocarcinoma,Cancer theranostics,RNAi

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