Lipophilicity is a key factor to increase the antiviral activity of HIV neutralizing antibodies.

Marcelo T Augusto,Axel Hollmann,Fulvia Troise,Ana S Veiga,Antonello Pessi,Nuno C Santos

Colloids and Surfaces B: Biointerfaces（2017）

引用 6|浏览12

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摘要

•HIV broadly neutralizing antibodies were conjugated to cholesterol.•A high membrane affinity was achieved for cholesterol-tagged antibodies.•High antiviral activity correlates with a strong membrane affinity.

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关键词

HIV-1,Antibodies,Antiviral,SPR,Membrane

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