Disseminated cytomegalovirus-associated hemophagocytic lymphohistiocytosis in an elderly patient.

TO THE EDITOR: Hemophagocytic lymphohistiocytosis (HLH) is characterized by severe immune activation and deregulation resulting in extreme and often life-threatening inflammation [1]. Adult-onset HLH is rare and fatal. Infectious agents contribute to a major part of the etiology of adult-onset HLH [2,3]. A high degree of clinical suspicion and prompt treatment is required to prevent mortality. We have described an unusual clinical presentation of a case of cytomegalovirus (CMV)-associated HLH with multi-organ involvement.