An NgAgo tool for genome editing: did CRISPR/Cas9 just find a competitor?
Genes & Diseases(2016)
Abstract
While CRISPR/Cas9-mediated genome editing technology has been experiencing a rapid transformation during the past few years, a recent report on NgAgo-mediated single-stranded DNA-guided genome editing may offer an attractive alternative for genome manipulation. While it's too early to predict whether NgAgo will be able to compete with or be superior to CRISPR/Cas9, the scientific community is anxiously waiting for further optimization and broader applications of the NgAgo genome editing technology.
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Key words
Argonautes,Cas9,CRISPR,Genome editing,gRNA guide,NgAgo,Nucleases,ssDNA guide
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